2-Chloro-4-fluoro-5-nitro-thiolbenzoic acid (methoxycarbonylmethyl) ester → 5-Amino-2-chloro-4-fluoro-thiolbenzoic acid (methoxycarbonylmethyl) ester

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Reaction Steps

10.4 g of the 2-chloro-4-fluoro-5-nitro-thiolbenzoic acid (methoxycarbonylmethyl) ester obtained in accordance with Example P1 are hydrogenated with hydrogen under normal pressure in 150 ml of tetrahydrofuran at a temperature of 20°-25° C. in the presence of 2 g of Raney nickel catalyst. After the stoichiometric amount of hydrogen has been consumed, the catalyst is separated off and the solution is concentrated by evaporation, yielding 8.6 g of 5-amino-2-chloro-4-fluoro-thiolbenzoic acid (methoxycarbonylmethyl) ester having a melting point of from +88° to +89° C.

Provenance & Evidence