(3S,5S,6S)-6-Cyclohexylmethyl-5-hydroxy-3-isopropylpiperidin-2-one → HCID 15219012, compound

HRID 484226Notes

Reaction equation

HRID 484226 reaction equation
C1(C[C@@H]2NC(=O)[C@H](C(C)C)C[C@@H]2O)CCCCC1.[CH2:19]([C@H:26]1[CH2:31][C@H:30]([OH:32])[C@H:29]([CH2:33][C:34]2[CH:39]=[CH:38][CH:37]=[CH:36][CH:35]=2)[NH:28][C:27]1=[O:40])[C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1>>[NH2:28][C@@H:29]([CH2:33][C:34]1[CH:39]=[CH:38][CH:37]=[CH:36][CH:35]=1)[C@H:30]1[O:32][C:27](=[O:40])[C@@H:26]([CH2:19][C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)[CH2:31]1

Participants

3

Reactant 2

HCID 10198938(3S,5S,6S)-6-Cyclohexylmethyl-5-hydroxy-3-isopropylpiperidin-2-oneHCID 57041890HCID 57041890, compound

Product 1

HCID 15219012HCID 15219012, compound

Procedure

Following the procedure described in Example 7 and replacing the product of Example 6 with the product of Example 9 provides the title product.

Sources & evidence

ORD record
ord-78c1ced0c10d4abcbf1179f72f7c561d
Source dataset
uspto-grants-1993_07
Patent number
US05229518

Reaction notes

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