1,4-Dioxane hydrochloride → 2-amino-5-((E)-2-(4-methylphenyl)ethenyl]indan hydrochloride

HRID 48424Notes

Reaction equation

HRID 48424 reaction equation
C(OC([NH:8][CH:9]1[CH2:17][C:16]2[C:11](=[CH:12][CH:13]=[C:14](/[CH:18]=[CH:19]/[C:20]3[CH:25]=[CH:24][C:23]([CH3:26])=[CH:22][CH:21]=3)[CH:15]=2)[CH2:10]1)=O)(C)(C)C.[ClH:27].O1CCOCC1>C(O)(=O)C>[ClH:27].[NH2:8][CH:9]1[CH2:17][C:16]2[C:11](=[CH:12][CH:13]=[C:14](/[CH:18]=[CH:19]/[C:20]3[CH:21]=[CH:22][C:23]([CH3:26])=[CH:24][CH:25]=3)[CH:15]=2)[CH2:10]1

Participants

4

Reactant 2

HCID 204431481,4-Dioxane hydrochlorideHCID 227196342-(tert-Butoxycarbonylamino)-5-[(E)-2-(4-methylphenyl)ethenyl]indan

Product 1

HCID 227195902-amino-5-((E)-2-(4-methylphenyl)ethenyl]indan hydrochloride

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

Using 2-(tert-butoxycarbonylamino)-5-((E)-2-(4-methylphenyl)ethenyl]indan (20 mg, 0.060 mmol) synthesized in Reference Production Example 2, 4N hydrochloric acid-dioxane (2.0 ml) and acetic acid (6.0 ml), a similar procedure to Production Example 213 was carried out to obtain 2-amino-5-((E)-2-(4-methylphenyl)ethenyl]indan hydrochloride (16 mg, 0.06 mmol) having the following physical properties:

Sources & evidence

ORD record
ord-24236d8f5f4d448390ff5c0d7596f342
Source dataset
uspto-grants-2004_03
Patent number
US06703421B1

Reaction notes

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