HCID 19746916, compound → HCID 19746915, compound

HRID 484268Notes

Reaction equation

HRID 484268 reaction equation
[OH:1][CH2:2][CH2:3][NH:4][C:5]1[CH:10]=[CH:9][CH:8]=[C:7]([N+:11]([O-])=O)[C:6]=1[CH3:14].[H][H]>[Ni].CO>[OH:1][CH2:2][CH2:3][NH:4][C:5]1[CH:10]=[CH:9][CH:8]=[C:7]([NH2:11])[C:6]=1[CH3:14]

Participants

5

Reactant 2

HCID 19746916HCID 19746916, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 19746915HCID 19746915, compound

Reagents, catalysts & solvents 2

HCID 935NickelCatalystHCID 887MethanolSolvent

Procedure

10 g of the 2-(β-hydroxyethylamino)-6-nitro-toluene prepared under Example 3, stage 2 are transferred to a stainless steel autoclave together with 200 ml of methanol, about 2 g of Raney nickel are added, and catalytic reduction is carried out with hydrogen under a hydrogen pressure of 20 bar at 70° C. in the course of 6 hours. After the catalyst has been removed, the mother liquor is concentrated and the product is isolated and dried.

Workup

  1. additionare added
  2. customat 70° C.
  3. customin the course of 6 hours
  4. customAfter the catalyst has been removed
  5. concentrationthe mother liquor is concentrated
  6. customthe product is isolated
  7. customdried

Sources & evidence

ORD record
ord-1cd13def5a5e4e25a634499eea83d617
Source dataset
uspto-grants-1993_07
Patent number
US05230710

Reaction notes

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