反应详情

A mixture of 66 g of 3-hydroxyphenethyl alcohol, 147.43 g of 1-bromotetradecane, 27.65 g of sodium hydroxide and 2.15 g of trioctylmethyl ammonium chloride in 400 ml of toluene was refluxed for 42 hours. The mixture was washed with water and the organic layer dried with magnesium sulfate. The solvent was removed in vacuo and the warm concentrate poured into 1 liter of hexanes. The resulting solid was washed with cold hexanes then dried giving 998.6 g of the desired compound as a white solid.

1. temperaturewas refluxed for 42 hours
2. washThe mixture was washed with water
3. dry with materialthe organic layer dried with magnesium sulfate
4. customThe solvent was removed in vacuo
5. concentrationthe warm concentrate
6. additionpoured into 1 liter of hexanes
7. washThe resulting solid was washed with cold hexanes
8. customthen dried