Sodium Hydroxide → HCID 19747228, compound

Participants

Reaction Steps

Acetic acid (25 ml) was added to 1 g of 8-cyano-11-[1-(2,2,2-trichloroethoxycarbonyl)-4-piperidylidene]-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridine to dissolve the latter, followed by the addition of 2.75 g of zinc powder. The resulting mixture was heated under stirring for 2.5 hours over an oil bath of 70°-80° C. After the reaction, the reaction mixture was basified with a sodium hydroxide solution and then extracted with chloroform. The extract was dried over anhydrous Na2SO4 and then filtered. The filtrate was concentrated under reduced pressure and the residue was purified by chromatography on a silica gel column. From relevant fractions eluted with chloroform:methanol (10:1), 0.41 g of 8-cyano-11-(4-piperidylidene)-6,11-dihydro-5H-benzo[5.6]cyclohepta[1,2-b]pyridine was obtained (yield: 65%).

Provenance & Evidence