Acetic Anhydride → HCID 19747243, compound

Participants

Reaction Steps

Pyridine (4 ml) was added to 0.4 g of 8-cyano-11-(4-piperidylidene)-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridine to dissolve the latter, followed by the addition of 8 ml of acetic anhydride. At the room temperature, the resulting mixture was stirred for 4 hours. After the completion of the reaction, the reaction mixture was concentrated under reduced pressure. Water was added to the residue, followed by extraction with chloroform. The extract was next dried over anhydrous Na2SO4 and the chloroform was distilled off under reduced pressure. The residue was purified by chromatography on a silica gel column and, from relevant fractions eluted with chloroform:methanol (100:1), 0.3 g of 8-cyano-11-(1-acetyl-4-piperidylidene)-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridine was obtained (yield: 66%).

Provenance & Evidence