HuagongsheHuagongshe Chemistry Print Report · For research reference only
1,2-Difluorobenzene → HCID 19746966, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1,2-Difluorobenzene | HCID 9706 | — |
| Reactant | Potassium | HCID 5462222 | — |
| Reactant | Potassium tert-butoxide | HCID 23665647 | — |
| Reactant | HCID 131718030 | HCID 131718030 | — |
| Reactant | Butyllithium | HCID 178418339 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 19746966 | HCID 19746966 | — |
Reaction Steps
2,3-Difluoro-4-pentylbenzoic acid is obtained by reacting o-difluorobenzene with butyllithium in the presence of potassium tertiary-butoxide at -90° to -100° in tetrahydrofuran, alkylating the potassium compound formed using pentyl bromide/1,3-dimethyltetrahydro-2-(1H)-pyrimidinone (DMPU), isolating the 2,3-difluoropentylbenzene, re-metallation by means of butyllithium and subsequent reaction with solid carbon dioxide.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05230827 |
| Source dataset | uspto-grants-1993_07 |
| ORD ID | ord-fbc1896aae944981ae426fb37363f163 |
| Source note | uspto-grants-1993_07 |