反应详情

A 1.8 g (6.7 mmol) amount of phosphorus tribromide was added to a chloroform solution (20 ml) of 3.3 g (20 mmol) of 5-phenyl-1-pentanol and the resulting solution was heated at reflux for 4 hours. When the reaction was traced by TLC, the starting materials were found to still remain in the reaction mixture, and so 0.2 g of phosphorus tribromide was further added and heated at reflux. Afterwards, the reaction solution was washed with water and dried with anhydrous magnesium sulfate, and then the solvent was evaporated under reduced pressure. Thus, 4.30 g of a crude 5-phenylpentyl bromide was obtained.

1. temperaturethe resulting solution was heated
2. temperatureat reflux for 4 hours
3. additionwas further added
4. temperatureheated
5. temperatureat reflux
6. washAfterwards, the reaction solution was washed with water
7. dry with materialdried with anhydrous magnesium sulfate
8. customthe solvent was evaporated under reduced pressure