Sodium Hydroxide → N-acetyl-neuraminic acid Sodium Salt

HRID 484377Notes

Reaction equation

HRID 484377 reaction equation
[C:1]([NH:4][C@H:5]1[C@H:14]([C@@H:15]([C@@H:17]([CH2:19][OH:20])[OH:18])[OH:16])[O:13][C:8]([OH:12])([C:9](=[O:11])[O-:10])[CH2:7][C@@H:6]1[OH:21])(=[O:3])[CH3:2].[OH-].[Na+:23]>O>[C:1]([NH:4][C@H:5]1[C@H:14]([C@@H:15]([C@@H:17]([CH2:19][OH:20])[OH:18])[OH:16])[O:13][C:8]([OH:12])([C:9](=[O:10])[O-:11])[CH2:7][C@@H:6]1[OH:21])(=[O:3])[CH3:2].[Na+:23]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 6857396Npc320186

Product 1

HCID 23662668N-acetyl-neuraminic acid Sodium Salt

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

500 g of N-acetylneuraminate was dissolved in 5,000 ml of water, 5 g of active carbon was added thereto and 1617 ml of a 1N sodium hydroxide solution was added to the solution in a nitrogen gas stream to adjust pH to 7.8. The reaction solution was filtered through a 0.2 μm filter and the filtrate was lyophilized to give 535 g (constant amount) of sodium N-acetylneuraminate as colorless powder.

Workup

  1. addition5 g of active carbon was added
  2. filtrationThe reaction solution was filtered through a 0.2 μm
  3. filtrationfilter

Sources & evidence

ORD record
ord-32a1b93e32404e2c8d78529311e8b04b
Source dataset
uspto-grants-1993_07
Patent number
US05231177

Reaction notes

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