1,4-Dioxane hydrochloride → 5-Acetoxy-2-aminoindan hydrochloride

HRID 48441Notes

Reaction equation

HRID 48441 reaction equation
[C:1]([O:4][C:5]1[CH:6]=[C:7]2[C:11](=[CH:12][CH:13]=1)[CH2:10][CH:9]([NH:14]C(OC(C)(C)C)=O)[CH2:8]2)(=[O:3])[CH3:2].[ClH:22].O1CCOCC1>C(O)(=O)C>[ClH:22].[C:1]([O:4][C:5]1[CH:6]=[C:7]2[C:11](=[CH:12][CH:13]=1)[CH2:10][CH:9]([NH2:14])[CH2:8]2)(=[O:3])[CH3:2]

Participants

4

Reactant 2

HCID 204431481,4-Dioxane hydrochlorideHCID 22719632HCID 22719632, compound

Product 1

HCID 227196415-Acetoxy-2-aminoindan hydrochloride

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

Using 5-acetoxy-2-(tert-butoxycarbonylamino)indan (120 mg, 0.40 mmol), 4N hydrochloric acid-dioxane (2 ml) and acetic acid (6 ml), a similar procedure to Production Example 213 was carried out to obtain 5-acetoxy-2-aminoindan hydrochloride (86 mg, 0.38 mmol) having the following physical properties:

Sources & evidence

ORD record
ord-3bfeb3a33934419fb6d0391f36aa0b23
Source dataset
uspto-grants-2004_03
Patent number
US06703421B1

Reaction notes

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