Hydrochloric Acid → HCID 67856678, compound

Participants

Reaction Steps

To a solution of cis-4-tertiary-butyloxycarbonylamino-2-carboxy-5,7-dichloro-1,2,3,4-tetrahydroquinoline (100 mg, 0.277 mmol) in ethyl acetate (5 ml) was added hydrogen chloride in ethyl acetate (5 ml of an approx. 5M solution) and the resulting mixture was stirred at room temperature for 2.5 h. The solvent was removed in vacuo and the residue was triturated with ethyl acetate. The solid was collected by filtration to give the title compound (0.073 g, m.p. 176°-178 g°C.); δ (360 MHz, D2O) 2.42 (1H, m, CHACHBHCCHD), 2.67 (1H, dm, J=15.6 Hz, CHACHBHCCHD 4.27 (1H, dd, J=6.6 and 1.7 Hz, CHACHBHCCHD), 4.90 (1H, dd, J=5.6 and 1.4 Hz, CHACHBHCCHD), 6.77 (1H, d, J=2.0 Hz, 6-H or 8-H), 6.88 (1H, d, J=2.0 Hz, 6-H or 8-H); m/e (FAB) 261 (M+1); Found: C, 40.17; H, 3.79; N, 9.23. C10H10Cl2N2O3.HCl requires C, 40.36; H, 3.73; N, 9.41%.

Provenance & Evidence