HCID 54253022, compound → HCID 14989187, compound

HRID 484480Notes

Reaction equation

HRID 484480 reaction equation
[CH2:1]([O:3][C:4]([N:6]1[CH2:10][CH2:9][CH:8]([CH:11]=[CH:12][C:13]([OH:15])=[O:14])[CH2:7]1)=[O:5])[CH3:2].[H][H]>[Pd].C(O)(=O)C>[CH2:1]([O:3][C:4]([N:6]1[CH2:10][CH2:9][CH:8]([CH2:11][CH2:12][C:13]([OH:15])=[O:14])[CH2:7]1)=[O:5])[CH3:2]

Participants

5

Reactant 2

HCID 54253022HCID 54253022, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 14989187HCID 14989187, compoundYield 100%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 176Acetic AcidSolvent

Procedure

A mixture of 13 parts of 3-[1-(ethoxycarbonyl)-3-pyrrolidinyl]-2-propenoic acid and 100 parts of acetic acid was hydrogenated at normal pressure and at 20° C. with 2 parts of palladium-on-charcoal catalyst 10%. After the calculated amount of hydrogen was taken up, the catalyst was filtered off and the filtrate was evaporated. The residue was taken up in methylbenzene and the latter was evaporated again, yielding 13 parts (100%) of 1-(ethoxycarbonyl) -3-pyrrolidinepropanoic acid as a residue (int. 28).

Workup

  1. filtrationthe catalyst was filtered off
  2. customthe filtrate was evaporated
  3. customthe latter was evaporated again

Sources & evidence

ORD record
ord-9e24e38a788145a48b33f307400566fd
Source dataset
uspto-grants-1993_07
Patent number
US05231184

Reaction notes

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