反应详情

To a stirred and cooled (15° C.) mixture of 11.1 parts of potassium hydroxide and 96 parts of water wa added dropwise a solution of 31.8 parts of ethyl 1-[(phenylmethoxy)carbonyl]-4-piperidinepropanoate in 38 parts of ethanol during 20 minutes. Upon complete addition, stirring was continued overnight at room temperature. The reaction mixture was evaporated at <50° C. The reaction mixture was poured into crushed ice and treated with concentrated hydrochloric acid. The separated aqueous layer was extracted with dichloromethane. The extract was dried, filtered and evaporated, yielding 29 parts (100%) of 1-[(phenylmethoxy)carbonyl]-4-piperidinepropanoic acid as a residue (int. 33).

1. temperaturecooled
2. additionUpon complete addition
3. stirringstirring
4. customThe reaction mixture was evaporated at <50° C
5. additionThe reaction mixture was poured
6. custominto crushed ice
7. additiontreated with concentrated hydrochloric acid
8. extractionThe separated aqueous layer was extracted with dichloromethane
9. customThe extract was dried
10. filtrationfiltered
11. customevaporated