HCID 14989208, compound → HCID 14989209, compound

HRID 484494Notes

Reaction equation

HRID 484494 reaction equation
[CH3:1][C:2]1([CH3:29])[CH2:6][O:5][C:4]([C:7]2[CH:28]=[CH:27][C:10]([O:11][CH2:12][CH2:13][CH:14]3[CH2:19][CH2:18][N:17](CC4C=CC=CC=4)[CH2:16][CH2:15]3)=[CH:9][CH:8]=2)=[N:3]1.[H][H]>[Pd].CO>[CH3:1][C:2]1([CH3:29])[CH2:6][O:5][C:4]([C:7]2[CH:8]=[CH:9][C:10]([O:11][CH2:12][CH2:13][CH:14]3[CH2:19][CH2:18][NH:17][CH2:16][CH2:15]3)=[CH:27][CH:28]=2)=[N:3]1

Participants

5

Reactant 2

HCID 14989208HCID 14989208, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 14989209HCID 14989209, compoundYield 86.4%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

A mixture of 5 parts of 4-[2-[4-(4,5-dihydro-4,4-dimethyl-2-oxazolyl)phenoxy]ethyl] -1-(phenylmethyl)piperidine and 120 parts of methanol was hydrogenated at normal pressure and at room temperature with 2 parts of palladium-on-charcoal catalyst 10%. After the calculated amount of hydrogen was taken up, the catalyst was filtered off and the filtrate was evaporated, yielding 3.4 parts (86.4%) of 4-[2-[4-(4,5-dihydro-4,4-dimethyl-2-oxazolyl)phenoxy]ethyl]piperidine as a residue (int. 75).

Workup

  1. filtrationthe catalyst was filtered off
  2. customthe filtrate was evaporated

Sources & evidence

ORD record
ord-aa2ef7899be64ff19130b96b2e0727dd
Source dataset
uspto-grants-1993_07
Patent number
US05231184

Reaction notes

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