反应详情

温度

145 °C

A mixture of 10.7 parts of methyl 4-[[4-hydroxy-1-(phenylmethyl)-4-piperidinyl]methoxy]benzoate and 8 parts of 2-aminoethanol was stirred for 4 hours in an oil bath at 145° C. After cooling, the reaction mixture was poured into water. The oil was decanted, washed twice with water and the product was extracted with dichloromethane. The extract was dried, filtered and evaporated. The residue was crystallized from a mixture of 2,2-oxybispropane and 2-propanol. The product was filtered off and dried yielding 8 parts (69.3%) of N-(2-hydroxyethyl)-4-[[4-hydroxy-1-(phenylmethyl)-4-piperidinyl]methoxy]benzamide; mp. 161.1° C. (int. 80).

1. temperatureAfter cooling
2. customThe oil was decanted
3. washwashed twice with water
4. extractionthe product was extracted with dichloromethane
5. customThe extract was dried
6. filtrationfiltered
7. customevaporated
8. customThe residue was crystallized from a mixture of 2,2-oxybispropane and 2-propanol
9. filtrationThe product was filtered off
10. customdried