Potassium Carbonate → HCID 14989340, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 3.9 parts of 3-chloro-6-[4-(2-chloroethyl) 1-piperidinyl]pyridazine, 2.64 parts of (2-propynyl) 4-hydroxybenzoate, 2.76 parts of potassium carbonate and 75 parts of N,N-dimethylacetamide was stirred overnight at 110° C. After cooling the reaction mixture was poured into 100 parts of water and the product was extracted with methylbenzene. The extract was dried, filtered and evaporated. The residue was purified by column chromatography over silica gel using a mixture of trichloromethane and methanol (98.2 by volume) as eluent. The pure fractions were collected and the eluent was evaporated. The residue was crystallized from 2-propanol. The product was filtered off and dried, yielding 5.2 parts (86.7%) of (2-propynyl) 4-[2-[1-(6-chloro-3-pyridazinyl) -4-piperidinyl]ethoxy]benzoate; mp. 122.0° C. (comp. 120).

Provenance & Evidence