Alanine-methacrylamide → HCID 178449942, compound

HRID 48454Notes

Reaction equation

HRID 48454 reaction equation
[C:1]([NH2:6])(=[O:5])[C:2]([CH3:4])=[CH2:3].[NH2:7][C@H:8]([C:10]([OH:12])=[O:11])[CH3:9].Cl.[C:14]([NH2:19])(=[O:18])[C:15]([CH3:17])=[CH2:16].[NH2:20][C@H:21]([C:29]([OH:31])=[O:30])[CH2:22][CH2:23][CH2:24][NH:25][C:26](=[NH:28])[NH2:27]>O.CO>[C:1]([NH2:6])(=[O:5])[C:2]([CH3:4])=[CH2:3].[NH2:7][C@H:8]([C:10]([OH:12])=[O:11])[CH3:9].[C:14]([NH2:19])(=[O:18])[C:15]([CH3:17])=[CH2:16].[NH2:20][C@H:21]([C:29]([OH:31])=[O:30])[CH2:22][CH2:23][CH2:24][NH:25][C:26](=[NH:27])[NH2:28]

Participants

5

Reactant 2

HCID 86759378Alanine-methacrylamideHCID 178449946HCID 178449946, compound

Product 1

HCID 178449942HCID 178449942, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 962WaterSolvent

Procedure

Alanine-methacrylamide(2.20 g) and 1.67 g of arginine-methacrylamide hydrochloride were dissolved in 15 ml of water, added 0.167 g of the fluorescence-labeled monomer dissolved in 15 ml of methanol, and bubbled with nitrogen gas for 1 hour. Potassium persulfate(0.060 g) was added to and dissolved in this solution, and the solution was refluxed by heating for 3 hours while maintaining nitrogen gas bubbling. The reaction mixture was poured into isopropanol to form precipitates. The supernatant was removed by decantation, and acetone was added again to the precipitates, and obtained mixture was stirred vigorously. The produced precipitates (powdered form) were collected by filtration, washed with acetone, and dried to obtain the target polymer.

Workup

  1. custombubbled with nitrogen gas for 1 hour
  2. additionPotassium persulfate(0.060 g) was added to and
  3. dissolutiondissolved in this solution
  4. temperaturethe solution was refluxed
  5. temperatureby heating for 3 hours
  6. temperaturewhile maintaining nitrogen gas
  7. custombubbling
  8. additionThe reaction mixture was poured into isopropanol
  9. customto form
  10. customprecipitates
  11. customThe supernatant was removed by decantation, and acetone
  12. additionwas added again to the precipitates
  13. customobtained mixture
  14. customThe produced precipitates (powdered form)
  15. filtrationwere collected by filtration
  16. washwashed with acetone
  17. customdried
  18. customto obtain the target polymer

Sources & evidence

ORD record
ord-4fe74769f9ed4d4ca60585b4d08e08ae
Source dataset
uspto-grants-2004_03
Patent number
US06703468B1

Reaction notes

Loading…