HCID 19748502, compound → 2-(1-AMINOETHYL)PHENOL HYDROCHLORIDE

HRID 484562Notes

Reaction equation

HRID 484562 reaction equation
[ClH:1].C([O:9][C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=1[CH:16]([NH2:18])[CH3:17])C1C=CC=CC=1>[Pd].CO>[ClH:1].[OH:9][C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=1[CH:16]([NH2:18])[CH3:17]

Participants

4

Reactant 1

HCID 19748502HCID 19748502, compound

Product 1

HCID 197485242-(1-AMINOETHYL)PHENOL HYDROCHLORIDEYield 102.4%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

A mixture obtained by adding 2.64 g of (+)-1-(2-benzyloxyphenyl)ethylamine hydrochloride prepared in Referential Example (3-1) and 0.26 g of 5% Pd-C to 40 ml of methanol was subjected to hydrogenation at room temperature and normal pressure, whereby 256 ml of hydrogen was absorbed. After filtering off the catalyst, the filtrate was concentrated under reduced pressure to give 1.78 g of (+)-1-(2-hydroxyphenyl)ethylamine hydrochloride.

Workup

  1. customA mixture obtained
  2. customwas subjected to hydrogenation at room temperature
  3. customnormal pressure, whereby 256 ml of hydrogen was absorbed
  4. filtrationAfter filtering off the catalyst
  5. concentrationthe filtrate was concentrated under reduced pressure

Sources & evidence

ORD record
ord-3cf72baeb0824305838f2c7f7b5f5347
Source dataset
uspto-grants-1993_07
Patent number
US05231227

Reaction notes

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