Tetrahydrofuran → [2-[4-(Tetradecyloxy)phenyl]ethyl]aminobenzenemethanol

Participants

Reaction Conditions

Reaction Steps

To a solution of 42.36 ml of 1 molar lithium aluminum hydride in either is added dropwise under argon over 20 minutes a solution of ethyl 3-[[[4-(tetradecyloxy)phenyl]acetyl]amino]benzoate in 50 ml of either and 50 ml of tetrahydrofuran. The mixture is refluxed for 3 hours, cooled to 0° C. and ethyl acetate added. Saturated sodium sulfate is added followed by ether. The mixture is filtered and the cake washed with ether. The filtrate is evaporated and the residue chromatographed on silica gel using 9:1 chloroform:ethyl acetate. The product fractions are combined and evaporated to a residue which is crystallized from hexane to give 4.5 g of the desired product as a white solid, m.p. 67°-70° C.

Provenance & Evidence