HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Hydroxybenzoic acid hydrazide → 4-(5-methyl-1,3,4-oxadiazol-2-yl)phenol(SALTDATA: FREE)
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Hydroxybenzoic acid hydrazide | HCID 1742 | — |
| Reactant | Triethyl orthoacetate | HCID 66221 | — |
| Product | 4-(5-methyl-1,3,4-oxadiazol-2-yl)phenol(SALTDATA: FREE) | HCID 5124602 | 99% |
Reaction Steps
A mixture of 9.6 parts of 4-hydroxybenzoic acid hydrazide and 44 parts of 1,1', 1"-[ethylidynetris(oxy)]trisethane is stirred and refluxed overnight. The precipitated product is filtered off and crystallized from 1-butanol, yielding 10.5 parts (99%) of 4-(5-methyl-1,3,4-oxadiazol-2-yl)phenol; mp. 238.8° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04533550 |
| Source dataset | uspto-grants-1985_08 |
| ORD ID | ord-2564984c1bad4ffd80d2fe67d1039f6a |
| Source note | uspto-grants-1985_08 |