Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | 5-Bromonicotinic acid | HCID 88707 | — |
| Reactant | 4-Fluorophenylboronic acid | HCID 285645 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Water | HCID 962 | — |
| Product | Emd-50929 | HCID 11378949 | — |
Reaction Steps
1.38 kg of 5-bromonicotinic acid, 1.10 kg of 4-fluorobenzeneboronic acid and 0.40 kg of Pd/activated carbon (5%) are introduced into 8.5 liters of water. The black suspension is rendered alkaline using 1.39 kg of 32% sodium hydroxide solution and warmed to 100° C. After 4 hours, the mixture is subjected to conventional work-up, giving 5-(4-fluorophenyl)nicotinic acid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US06703509B2 |
|---|
| Source dataset | uspto-grants-2004_03 |
|---|
| ORD ID | ord-471ca8150fbd4c65ab045f4e7161b78a |
|---|
| Source note | uspto-grants-2004_03 |
|---|
