HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Amino-6-Chloropyrazine → N-(6-chloro-pyrazin-2-yl)-2-ethyl-4-hydroxy-2H-1,2-benzothiazine-3-carboxamide-1,1-dioxide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Amino-6-Chloropyrazine | HCID 118458 | — |
| Reactant | methyl 2-ethyl-4-hydroxy-2H-1,2-benzothiazine-3-carboxylate 1,1-dioxide | HCID 54703133 | — |
| Solvent | O-Xylene | HCID 7237 | — |
| Product | N-(6-chloro-pyrazin-2-yl)-2-ethyl-4-hydroxy-2H-1,2-benzothiazine-3-carboxamide-1,1-dioxide | HCID 54703125 | 64% |
Reaction Steps
8.5 g (30 mmols) of methyl 2-ethyl-4-hydroxy-2H-1,2-benzothiazine-3-carboxylate-1,1-dioxide and 3.9 g (30 mmols) of 2-amino-6-chloro-pyrazine were reacted in 600 ml of xylene and worked up analogous to Example 1, yielding 7.3 g (64% of theory) of N-(6-chloro-pyrazin-2-yl)-2-ethyl-4-hydroxy-2H-1,2-benzothiazine-3-carboxamide-1,1-dioxide.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04533664 |
| Source dataset | uspto-grants-1985_08 |
| ORD ID | ord-83e04f02f7e14188b9a5a4aaca6fac0e |
| Source note | uspto-grants-1985_08 |