HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Amino-6-Chloropyrazine → N-(6-chloro-pyrazin-2-yl)-4-hydroxy-2-n-propyl-2H-1,2-benzothiazine-3-carboxamide-1,1-dioxide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Amino-6-Chloropyrazine | HCID 118458 | — |
| Reactant | Methyl 4-hydroxy-2-propyl-2H-1,2-benzothiazine-3-carboxylate 1,1-dioxide | HCID 54703140 | — |
| Solvent | O-Xylene | HCID 7237 | — |
| Product | N-(6-chloro-pyrazin-2-yl)-4-hydroxy-2-n-propyl-2H-1,2-benzothiazine-3-carboxamide-1,1-dioxide | HCID 54703123 | 52% |
Reaction Steps
2.97 g (10 mmols) of methyl 2-n-propyl-4-hydroxy-2H-1,2-benzothiazine-3-carboxylate-1,1-dioxide and 1.3 g (10 mmols) of 2-amino-6-chloro-pyrazine were reacted in 150 ml of xylene analogous to Example 1, yielding 2.05 g (52% of theory) of N-(6-chloro-pyrazin-2-yl)-4-hydroxy-2-n-propyl-2H-1,2-benzothiazine-3-carboxamide-1,1-dioxide.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04533664 |
| Source dataset | uspto-grants-1985_08 |
| ORD ID | ord-0867c641bf6348c59f4dcd76a87d379e |
| Source note | uspto-grants-1985_08 |