2-Amino-6-Chloropyrazine → N-(6-chloro-pyrazin-2-yl)-4-hydroxy-2-methyl-2H-1,2-benzothiazine-3-carboxamide-1,1-dioxide

HRID 484697Notes

Reaction equation

HRID 484697 reaction equation
[OH:1][C:2]1[C:7]2[CH:8]=[CH:9][CH:10]=[CH:11][C:6]=2[S:5](=[O:13])(=[O:12])[N:4]([CH3:14])[C:3]=1[C:15]([O:17]CC1C=CC=CC=1)=O.[NH2:25][C:26]1[CH:31]=[N:30][CH:29]=[C:28]([Cl:32])[N:27]=1>>[Cl:32][C:28]1[N:27]=[C:26]([NH:25][C:15]([C:3]2[N:4]([CH3:14])[S:5](=[O:12])(=[O:13])[C:6]3[CH:11]=[CH:10][CH:9]=[CH:8][C:7]=3[C:2]=2[OH:1])=[O:17])[CH:31]=[N:30][CH:29]=1

Participants

3

Reactant 2

HCID 1184582-Amino-6-ChloropyrazineHCID 54703132benzyl 4-hydroxy-2-methyl-2H-1,2-benzothiazine-3-carboxylate-1,1-dioxide

Product 1

HCID 54703135N-(6-chloro-pyrazin-2-yl)-4-hydroxy-2-methyl-2H-1,2-benzothiazine-3-carboxamide-1,1-dioxide

Procedure

This compound was prepared from benzyl 4-hydroxy-2-methyl-2H-1,2-benzothiazine-3-carboxylate-1,1-dioxide and 2-amino-6-chloro-pyrazine analogous to Example 1.

Sources & evidence

ORD record
ord-fb22bf10c8cb40e087e862d6c4ad9be2
Source dataset
uspto-grants-1985_08
Patent number
US04533664

Reaction notes

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