Ethanone, 1-(9H-fluoren-2-yl)-2-(1H-imidazol-1-yl)- → HCID 13520042, compound

HRID 484744Notes

Reaction equation

HRID 484744 reaction equation
[BH4-].[Na+].[N:3]1([CH2:8][C:9]([C:11]2[CH:23]=[CH:22][C:21]3[C:20]4[C:15](=[CH:16][CH:17]=[CH:18][CH:19]=4)[CH2:14][C:13]=3[CH:12]=2)=[O:10])[CH:7]=[CH:6][N:5]=[CH:4]1>C(O)C>[CH:12]1[C:13]2[CH2:14][C:15]3[C:20](=[CH:19][CH:18]=[CH:17][CH:16]=3)[C:21]=2[CH:22]=[CH:23][C:11]=1[CH:9]([OH:10])[CH2:8][N:3]1[CH:7]=[CH:6][N:5]=[CH:4]1

Participants

4

Reactant 2

HCID 57350Ethanone, 1-(9H-fluoren-2-yl)-2-(1H-imidazol-1-yl)-HCID 4311764Sodium borohydride

Product 1

HCID 13520042HCID 13520042, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Two grams of sodium borohydride were added in portions to a stirred suspension of ten grams of 2-(1H-imidazol-1-yl)-1-(9H-fluoren-2-yl)ethanone in 100 ml. of ethanol at room temperature. After one hour, the reaction mixture was poured into 700 ml. of water and the resulting precipitate was recovered by filtration. Crystallization of the solid from tetrahydrofuran/hexane provided 9.7 g. of the desired title product, m.p. 196°-199° C.

Workup

  1. customat room temperature
  2. additionthe reaction mixture was poured into 700 ml
  3. filtrationof water and the resulting precipitate was recovered by filtration
  4. customCrystallization of the solid from tetrahydrofuran/hexane
  5. customprovided 9.7 g

Sources & evidence

ORD record
ord-21f627e43638498a976f3d99bb70fd99
Source dataset
uspto-grants-1985_08
Patent number
US04533670

Reaction notes

Loading…