Sodium borohydride → HCID 13520043, compound

HRID 484745Notes

Reaction equation

HRID 484745 reaction equation
[CH:1]1[C:13]2[CH2:12][C:11]3[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=3)[C:5]=2[CH:4]=[CH:3][C:2]=1[C:14](=[O:22])[CH2:15][CH2:16][N:17]1[CH:21]=[CH:20][N:19]=[CH:18]1.[BH4-].[Na+]>>[CH:1]1[C:13]2[CH2:12][C:11]3[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=3)[C:5]=2[CH:4]=[CH:3][C:2]=1[CH:14]([OH:22])[CH2:15][CH2:16][N:17]1[CH:21]=[CH:20][N:19]=[CH:18]1

Participants

3

Reactant 2

HCID 4311764Sodium borohydrideHCID 13520034HCID 13520034, compound

Product 1

HCID 13520043HCID 13520043, compoundYield 72%

Procedure

Following the procedure of Example 14, 1-(9H-fluoren-2-yl)-3-(1H-imidazol-1-yl)-1-propanone was reduced with sodium borohydride to provide a 72% yield of the title product, m.p. 143.5°-145.5° C.

Sources & evidence

ORD record
ord-aa76e6f6f48b40fc91b73d607c47a302
Source dataset
uspto-grants-1985_08
Patent number
US04533670

Reaction notes

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