4-(Trifluoromethoxy)aniline → HCID 13251606, compound

Participants

Reaction Conditions

Reaction Steps

2.99 g (0.015 mol) of 2-chloro-5-fluoro-benzoyl isocyanate are added to 2.66 g (0.015 mol) of 4-trifluoromethoxyaniline in 30 ml of dry toluene, at 60° C., in the absence of moisture. The mixture is stirred for one hour at 80° C. and cooled to 20°-25° C. The precipitated product is filtered off under suction and dried in vacuo at 100° C. 5.6 g (100% of theory) of 1-(2-chloro-5-fluoro-benzoyl)-3-(4-trifluoromethoxyphenyl)-urea of melting point 199° C. are obtained.

Provenance & Evidence