Phosphorus pentachloride → Ethoxy(4-phenylbutyl)phosphinyl chloride

HRID 484757Notes

Reaction equation

HRID 484757 reaction equation
[CH2:1]([O:3][P:4]([CH2:9][CH2:10][CH2:11][CH2:12][C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1)(=O)[O:5]CC)[CH3:2].P(Cl)(Cl)(Cl)(Cl)[Cl:20]>C1C=CC=CC=1>[CH2:1]([O:3][P:4]([Cl:20])([CH2:9][CH2:10][CH2:11][CH2:12][C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1)=[O:5])[CH3:2]

Participants

4

Reactant 2

HCID 24819Phosphorus pentachlorideHCID 13102400Diethyl 4-phenylbutylphosphonate

Product 1

HCID 15591238Ethoxy(4-phenylbutyl)phosphinyl chloride

Reagents, catalysts & solvents 1

HCID 241BenzeneSolvent

Procedure

A mixture of diethyl(4-phenylbutyl)phosphonate (0.73 g., 2.6 mmole), benzene (10 ml.) and phosphorus pentachloride (1.0 eq.) is refluxed under argon for 30 minutes. The benzene and phosphorus oxychloride are removed in vacuo to give ethoxy(4-phenylbutyl)phosphinyl chloride.

Workup

  1. temperatureis refluxed under argon for 30 minutes
  2. customThe benzene and phosphorus oxychloride are removed in vacuo

Sources & evidence

ORD record
ord-8394bff2081c4a9b824756f499a0798d
Source dataset
uspto-grants-1985_08
Patent number
US04533661

Reaction notes

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