反应详情

(R)-1-Methyl-3-phenylpropanamine hydrochloride was prepared by first esterifying N-(tert-butyloxycarbonyl)-D-alanine with diazomethane, then reducing the resulting N-(tert-butyloxycarbonyl)-D-alanine methyl ester with diisobutylaluminum hydride, then condensing the resulting N-(tert-butyloxycarbonyl)-D-alaninal with benzylidenetriphenylphosphonium ylide, then hydrogenating over palladium catalyst the resulting [R-(E)]-N-(tert-butyloxycarbonyl)-1-methyl-3-phenyl-2-propenamine having m.r. 86°-88° C. and [α]D25 +54.0° (c=1, methanol), and finally deprotecting with hydrogen chloride in dioxane the resulting (R)-N-(tert-butyloxycarbonyl)-1-methyl-3-phenylpropanamine having m.r. 74°-76° C. and [α]D25 +7.2° (c=1, methanol). ##STR16##