Boc-Tyr(tBu)-OH → HCID 70485509, compound

HRID 484773Notes

Reaction equation

[C:1]([O:5][C:6]([NH:8][C@H:9]([C:22]([OH:24])=O)[CH2:10][C:11]1[CH:16]=[CH:15][C:14]([O:17][C:18]([CH3:21])([CH3:20])[CH3:19])=[CH:13][CH:12]=1)=[O:7])([CH3:4])([CH3:3])[CH3:2].Cl.[CH3:26][S:27][CH2:28][CH2:29][CH2:30][N:31]([CH2:37][CH2:38][CH2:39][C:40]1[CH:45]=[CH:44][CH:43]=[CH:42][CH:41]=1)[C:32](=[O:36])[C@@H:33]([CH3:35])[NH2:34]>>[C:1]([O:5][C:6]([NH:8][C@H:9]([C:22]([NH:34][C@@H:33]([C:32]([N:31]([CH2:30][CH2:29][CH2:28][S:27][CH3:26])[CH2:37][CH2:38][CH2:39][C:40]1[CH:41]=[CH:42][CH:43]=[CH:44][CH:45]=1)=[O:36])[CH3:35])=[O:24])[CH2:10][C:11]1[CH:12]=[CH:13][C:14]([O:17][C:18]([CH3:20])([CH3:21])[CH3:19])=[CH:15][CH:16]=1)=[O:7])([CH3:4])([CH3:3])[CH3:2]

Participants

Reactant 2

HCID 7017901Boc-Tyr(tBu)-OH

HCID 70485206HCID 70485206, compound

Product 1

HCID 70485509HCID 70485509, compound

Procedure

By the method of part B of Example 8, N-(tert-butyloxycarbonyl)-O-(tert-butyl)-L-tyrosine (1.50 g.) was condensed with N-[3-(methylthio)propyl]-N-(3-phenylpropyl)-D-alaninamide hydrochloride (1.470 g.), affording N-(tert-butyloxycarbonyl)-O-(tert-butyl)-L-tyrosyl-N-[3-(methylthio)propyl]-N-(3-phenylpropyl)-D-alaninamide as a viscous oil (2.716 g.). ##STR21##

Sources & evidence

ORD record: ord-79604b538e31418e9da4086d2c194e09
Source dataset: uspto-grants-1985_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04533657

Reaction notes

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