Acetyl chloride → 2-[(2-Methyl-4-acetamidopheny)amino]-1-pyrroline, hydrochloride

Participants

Reaction Steps

A mixture of 1.0 g (3.8 mmole) of the product compound of Example 9 and 30.5 mmole of acetyl chloride in 40 ml of acetonitrile was stirred at room temperature for 18 to 20 hours. The reaction mixture was then diluted eight-fold with diethyl ether. The resultant solid was collected and washed with three portions of ether, then dried in a high vacuum over 5A molecular sieves, giving the title compound as the hydrochloride salt. Structure assignment was supported by the nmr spectrum and by elemental analysis.

Provenance & Evidence