Chloroacetyl chloride → 2-[(2-Methyl-4-(chloroacetamido)phenyl)amino]-1-pyrroline, hydrochloride

HRID 484792Notes

Reaction equation

[Cl:1][CH2:2][C:3](Cl)=[O:4].Cl.Cl.[CH3:8][C:9]1[CH:14]=[C:13]([NH2:15])[CH:12]=[CH:11][C:10]=1[NH:16][C:17]1[CH2:21][CH2:20][CH2:19][N:18]=1>>[ClH:1].[CH3:8][C:9]1[CH:14]=[C:13]([NH:15][C:3](=[O:4])[CH2:2][Cl:1])[CH:12]=[CH:11][C:10]=1[NH:16][C:17]1[CH2:21][CH2:20][CH2:19][N:18]=1

Participants

Reactant 2

HCID 6577Chloroacetyl chloride

HCID 1317142942-[(2-Methyl-4-aminophenyl)amino]-1-pyrroline, dihydrochloride

Product 1

HCID 704773862-[(2-Methyl-4-(chloroacetamido)phenyl)amino]-1-pyrroline, hydrochloride

Procedure

The title compound was prepared by the method of Example 16 using 30.5 mmole of chloroacetyl chloride and 1.0 g (3.8 mmole) of the product compound of Example 9. Structure assignment was supported by the nmr spectrum and by elemental analysis.

Sources & evidence

ORD record: ord-d2aabcae855f4582951746657ba9d6af
Source dataset: uspto-grants-1985_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04533739

Reaction notes

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