Diethyl Ether → 2-[[2-Methyl-4-((3-hydroxypropyloxy)carbonylamino)phenyl]amino]-1-pyrroline, hydrochloride

Participants

Reaction Steps

The title compound was prepared by the general method of Example 25 using the product compound of Example 9 and 1,3-propanediol. The reaction mixture was treated with an eight-fold quantity of diethyl ether, in which the product was not soluble. The oily product was triturated with several portions of ether until solid. The crude solid was stirred as a suspension in a small amount of 1:1 ethanol/methanol, and then collected by filtration. Drying in a high vacuum over 5A molecular sieves produced the desired compound as the hydrochloride salt.

Provenance & Evidence