Ethyl chloroformate → 2-[(2-Methyl-3-(ethoxycarbonylamino)phenyl)-amino]-1-pyrroline, hydrochloride

HRID 484809Notes

Reaction equation

[Cl:1][C:2]([O:4][CH2:5][CH3:6])=[O:3].Cl.Cl.[CH3:9][C:10]1[C:15]([NH2:16])=[CH:14][CH:13]=[CH:12][C:11]=1[NH:17][C:18]1[CH2:22][CH2:21][CH2:20][N:19]=1>>[ClH:1].[CH3:9][C:10]1[C:15]([NH:16][C:2]([O:4][CH2:5][CH3:6])=[O:3])=[CH:14][CH:13]=[CH:12][C:11]=1[NH:17][C:18]1[CH2:22][CH2:21][CH2:20][N:19]=1

Participants

Reactant 2

HCID 10928Ethyl chloroformate

HCID 699300682-[(2-Methyl-3-aminophenyl)amino]-1-pyrroline, dihydrochloride

Product 1

HCID 179160432-[(2-Methyl-3-(ethoxycarbonylamino)phenyl)-amino]-1-pyrroline, hydrochloride

Procedure

The title compound (2.2 g) was prepared by the method of Example 23 using ethyl chloroformate and 3.0 g of the product aniline of Example 45. Structure assignment was supported by the nmr spectrum and by elemental analysis.

Sources & evidence

ORD record: ord-dc56dd13743e4c738b81edb676b3a169
Source dataset: uspto-grants-1985_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04533739

Reaction notes

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