反应详情

To 60 ml of absolute methyl alcohol were added 10 g of 4-phenoxy-2-butyl tosylate and 5.93 g of dimethylamine. The mixture was reacted in a sealed tube for one hour at 125° C. After the reaction solution was condensed under reduced pressure, 100 ml of diethyl ether was added into the solution and the solution was separated into the diethyl ether solution and 20% aqueous sodium hydroxide solution. The ether layer was dried over anhydrous sodium sulfate, and then the ether was removed under reduced pressure therefrom. The residue thus obtained was subjected to an alumina-column chromatography using chloroform as the developing solvent to give 3.98 g of 1-methyl-3-phenoxypropyldimethylamine in a yield of 66%.

1. customThe mixture was reacted in a sealed tube for one hour at 125° C
2. additionwas added into the solution
3. customthe solution was separated into the diethyl ether solution and 20% aqueous sodium hydroxide solution
4. dry with materialThe ether layer was dried over anhydrous sodium sulfate
5. customthe ether was removed under reduced pressure
6. customThe residue thus obtained