1H-indazol-3-amine → 1,3-Propanediamine, N,N-diethyl-N'-(1H-indazol-3-yi)-

HRID 484867Notes

Reaction equation

HRID 484867 reaction equation
[CH2:1]([N:3]([CH2:18][CH3:19])[CH2:4][CH2:5][CH2:6][NH:7][C:8]1[C:16]2[C:11](=[CH:12][CH:13]=[C:14](I)[CH:15]=2)[NH:10][N:9]=1)[CH3:2].NC1C2C(=CC=CC=2)NN=1>>[CH2:18]([N:3]([CH2:1][CH3:2])[CH2:4][CH2:5][CH2:6][NH:7][C:8]1[C:16]2[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=2)[NH:10][N:9]=1)[CH3:19]

Participants

3

Reactant 2

HCID 133991H-indazol-3-amineHCID 20135848N~1~,N~1~-Diethyl-N~3~-(5-iodo-1H-indazol-3-yl)propane-1,3-diamine

Product 1

HCID 30680431,3-Propanediamine, N,N-diethyl-N'-(1H-indazol-3-yi)-Yield 54%

Procedure

The same procedures for preparing 3-(3-diethylaminopropylamino)-5-iodoindazole as described in Example 71 were repeated except that 4.0 g of 3-aminoindazole was employed instead of the 9.7 g of 3-amino-5-iodoindazole. As a result, 4.0 g of 3-(3-diethylaminopropylamino)indazole having the following analytical values was obtained in a yield of 54%.

Sources & evidence

ORD record
ord-4d0540c1469c41e4b700dcc5747cfac4
Source dataset
uspto-grants-1985_08
Patent number
US04533731

Reaction notes

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