HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Amino-4-chloroindazole → 1-(3-Morpholinopropyl)-3-amino-5-chloroindazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Amino-4-chloroindazole | HCID 313444 | — |
| Reactant | (3-Bromopropyl)diethylamine hydrobromide | HCID 12639158 | — |
| Reactant | 1-(3-Diethylaminopropyl)-3-amino-4-chloroindazole | HCID 13229325 | — |
| Reactant | 4-(3-Bromopropyl)morpholine hydrobromide | HCID 21509538 | — |
| Reactant | 3-Amino-5-chloro-1h-indazole | HCID 21516164 | — |
| Product | 1-(3-Morpholinopropyl)-3-amino-5-chloroindazole | HCID 20135763 | 110.7% |
Reaction Steps
The same procedures for preparing 1-(3-diethylaminopropyl)-3-amino-4-chloroindazole as described in Example 89 were repeated except that 5.03 g of 3-bromopropylmorpholine hydrobromide and 5.66 g of 3-amino-5-chloroindazole were employed instead of the 3-bromopropyldiethylamine hydrobromide and the 3-amino-4-chloroindazole, respectively. As a result, 5.68 g of 1-(3-morpholinopropyl)-3-amino-5-chloroindazole was obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04533731 |
| Source dataset | uspto-grants-1985_08 |
| ORD ID | ord-7516581f02ab4d35a45e102a08ce7c41 |
| Source note | uspto-grants-1985_08 |