HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-(1H-Indazol-3-yl)-1H-isoindole-1,3(2H)-dione → 1-(3-Dimethylaminobutyl)-3-aminoindazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-(1H-Indazol-3-yl)-1H-isoindole-1,3(2H)-dione | HCID 2755857 | — |
| Reactant | (3-Bromopropyl)diethylamine hydrobromide | HCID 12639158 | — |
| Reactant | 1-(3-Diethylaminopropyl)-3-amino-4-chloroindazole | HCID 13229325 | — |
| Reactant | 2-(4-chloro-1H-indazol-3-yl)isoindoline-1,3-dione | HCID 13229771 | — |
| Reactant | 1-Methyl-3-bromopropyldimethylamine hydrobromide | HCID 20135791 | — |
| Product | 1-(3-Dimethylaminobutyl)-3-aminoindazole | HCID 13210585 | — |
Reaction Steps
The same procedures for preparing 1-(3-diethylaminopropyl)-3-amino-4-chloroindazole as described in Example 89 were repeated except that 8 g of 3-phthalimidoindazole and 8.6 g of (1-methyl-3-bromopropyl)dimethylamine hydrobromide were employed instead of the 3-phthalimido-4-chloroindazole and the 3-bromopropyldiethylamine hydrobromide, respectively. As a result, 9.2 g of 1-(3-dimethylaminobutyl)-3-aminoindazole was obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04533731 |
| Source dataset | uspto-grants-1985_08 |
| ORD ID | ord-358c3a0fa6be44a590f476e139a8bfb8 |
| Source note | uspto-grants-1985_08 |