HuagongsheHuagongshe Chemistry Print Report · For research reference only
1H-indazol-3-amine → 1-[3-(Morpholin-4-yl)butyl]-1H-indazol-3-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1H-indazol-3-amine | HCID 13399 | — |
| Reactant | 3-Amino-4-chloroindazole | HCID 313444 | — |
| Reactant | (3-Bromopropyl)diethylamine hydrobromide | HCID 12639158 | — |
| Reactant | 4-(4-Bromobutan-2-yl)morpholine--hydrogen bromide (1/1) | HCID 70352737 | — |
| Product | 1-[3-(Morpholin-4-yl)butyl]-1H-indazol-3-amine | HCID 13210580 | 48% |
Reaction Steps
The same procedures as described in Example 1 were repeated except that 4.50 g of 3-aminoindazole and 5.03 g of (1-methyl-3-bromopropyl)-morpholine hydrobromide were employed instead of the 5.66 g of 3-amino-4-chloroindazole and the 4.83 g of 3-bromopropyldiethylamine hydrobromide, respectively. As a result, 1-(3-morpholinobutyl)-3-aminoindazole having the following analytical values was obtained in a yield of 48%.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04533731 |
| Source dataset | uspto-grants-1985_08 |
| ORD ID | ord-3ab88c255aef4b8d8aa2545d9343cb02 |
| Source note | uspto-grants-1985_08 |