Cyanuric chloride → HCID 20272125, compound

Participants

Reaction Steps

A solution of 12.0 g of cyanuric chloride in 100 ml of xylene was added dropwise at 20°-25° C. to a solution of 54.0 g of 2,2,6,6-tetramethyl-4-(octadecylamino)piperidine in 200 ml of xylene. The resulting mixture was then heated under reflux for 8 hours, after which it was neutralised with an aqueous solution of potassium carbonate and then extracted with benzene. The extract was dried over anhydrous potassium carbonate and then the solvent was distilled off. The resulting residue was purified by column chromatography through silica gel, eluted with a 20:1:1 by volume mixture of ethyl acetate, ethanol and triethylamine, to give the title compound in the form of crystals. These were recrystallised from ethyl acetate, giving the purified title compound in the form of colourless crystals melting at 68°-70° C.

Provenance & Evidence