HRID484946

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID94211

1,8-Octanediamine, 4-(aminomethyl)-

C9H23N3

结构：COCCCN(c1nc(Cl)nc(N(CCCOC)C2CC(C)(C)NC(C)(C)C2)n1)C1CC(C)(C)NC(C)(C)C1

HCID11970672

6-Chloro-N~2~,N~4~-bis(3-methoxypropyl)-N~2~,N~4~-bis(2,2,6,6-tetramethylpiperidin-4-yl)-1,3,5-triazine-2,4-diamine

C29H54ClN7O2

PRODUCTS

生成物

结构：COCCCN(c1nc(NCCCCC(CCCNc2nc(N(CCCOC)C3CC(C)(C)NC(C)(C)C3)nc(N(CCCOC)C3CC(C)(C)NC(C)(C)C3)n2)CNc2nc(N(CCCOC)C3CC(C)(C)NC(C)(C)C3)nc(N(CCCOC)C3CC(C)(C)NC(C)(C)C3)n2)nc(N(CCCOC)C2CC(C)(C)NC(C)(C)C2)n1)C1CC(C)(C)NC(C)(C)C1

HCID20272127

未命名化合物

PROCEDURE

实验过程

Following the procedure described in Example 1, 2-chloro-4,6-bis[N-(3-methoxypropyl)-N-(2,2,6,6-tetramethyl-4-piperidyl)amino]-1,3,5-triazine [prepared as described in Preparation 6(b)] and 1,8-diamino-4-aminomethyloctane were reacted together and the reaction mixture treated to yield a residue, which was purified by column chromatography through silica gel, eluted with 4:1:1 by volume mixture of ethyl acetate, ethanol and triethylamine, to give the desired Compound No. 32, in the form of crystals melting at 96°-99° C.

WORKUP

后处理

customwere reacted together
additionthe reaction mixture treated
customto yield a residue, which
customwas purified by column chromatography through silica gel
washeluted with 4:1:1 by volume mixture of ethyl acetate, ethanol and triethylamine

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-fa56022b50cf4df5b63b4eb2171665b4
来源数据集: uspto-grants-1985_08
DOI: 10.6084/m9.figshare.5104873.v1
专利: US04533688
来源说明: uspto-grants-1985_08

反应 SMILES

Cl[C:2]1[N:7]=[C:6]([N:8]([CH2:19][CH2:20][CH2:21][O:22][CH3:23])[CH:9]2[CH2:14][C:13]([CH3:16])([CH3:15])[NH:12][C:11]([CH3:18])([CH3:17])[CH2:10]2)[N:5]=[C:4]([N:24]([CH:30]2[CH2:35][C:34]([CH3:37])([CH3:36])[NH:33][C:32]([CH3:39])([CH3:38])[CH2:31]2)[CH2:25][CH2:26][CH2:27][O:28][CH3:29])[N:3]=1.[NH2:40][CH2:41][CH2:42][CH2:43][CH:44]([CH2:50][NH2:51])[CH2:45][CH2:46][CH2:47][CH2:48][NH2:49]>>[CH3:29][O:28][CH2:27][CH2:26][CH2:25][N:24]([C:4]1[N:5]=[C:6]([N:8]([CH:9]2[CH2:14][C:13]([CH3:15])([CH3:16])[NH:12][C:11]([CH3:17])([CH3:18])[CH2:10]2)[CH2:19][CH2:20][CH2:21][O:22][CH3:23])[N:7]=[C:2]([NH:40][CH2:41][CH2:42][CH2:43][CH:44]([CH2:50][NH:51][C:2]2[N:7]=[C:6]([N:8]([CH2:19][CH2:20][CH2:21][O:22][CH3:23])[CH:9]3[CH2:14][C:13]([CH3:16])([CH3:15])[NH:12][C:11]([CH3:17])([CH3:18])[CH2:10]3)[N:5]=[C:4]([N:24]([CH:30]3[CH2:31][C:32]([CH3:39])([CH3:38])[NH:33][C:34]([CH3:36])([CH3:37])[CH2:35]3)[CH2:25][CH2:26][CH2:27][O:28][CH3:29])[N:3]=2)[CH2:45][CH2:46][CH2:47][CH2:48][NH:49][C:2]2[N:3]=[C:4]([N:24]([CH:30]3[CH2:31][C:32]([CH3:38])([CH3:39])[NH:33][C:34]([CH3:37])([CH3:36])[CH2:35]3)[CH2:25][CH2:26][CH2:27][O:28][CH3:29])[N:5]=[C:6]([N:8]([CH:9]3[CH2:10][C:11]([CH3:18])([CH3:17])[NH:12][C:13]([CH3:16])([CH3:15])[CH2:14]3)[CH2:19][CH2:20][CH2:21][O:22][CH3:23])[N:7]=2)[N:3]=1)[CH:30]1[CH2:31][C:32]([CH3:39])([CH3:38])[NH:33][C:34]([CH3:37])([CH3:36])[CH2:35]1