Methanol → Methyl 2-bromo-4-methylpentanoate

HRID 484962Notes

Reaction equation

HRID 484962 reaction equation
[Br:1][CH:2]([CH2:6][CH:7]([CH3:9])[CH3:8])[C:3](Cl)=[O:4].[CH3:10][OH:11]>>[CH3:10][O:11][C:3](=[O:4])[CH:2]([Br:1])[CH2:6][CH:7]([CH3:9])[CH3:8]

Participants

3

Reactant 2

HCID 887MethanolHCID 135203652-Bromo-4-methylpentanoyl chloride

Product 1

HCID 12957039Methyl 2-bromo-4-methylpentanoate

Procedure

2-Bromo-4-methylpentanoyl chloride (IV, Example 2) is added dropwise to methyl alcohol (200 ml.) at 0°. After two hours the methanol is removed under reduce pressure and the residual oil is partitioned between chloroform and water. The chloroform is separated from the water and removed under reduced pressure to give a residual oil which is distilled under reduced pressure to give the title compound, b.p. 78°-90°/30 mm.

Workup

  1. customAfter two hours the methanol is removed
  2. customthe residual oil is partitioned between chloroform and water
  3. customThe chloroform is separated from the water
  4. customremoved under reduced pressure
  5. customto give a residual oil which
  6. distillationis distilled under reduced pressure

Sources & evidence

ORD record
ord-ef708403d1f1434c8a3eed888161b871
Source dataset
uspto-grants-1985_08
Patent number
US04534897

Reaction notes

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