1,4-Bis(phenylmethyl)piperazinone, hydrochloride → 1-Benzylpiperazin-2-one hydrochloride

HRID 484967Notes

Reaction equation

HRID 484967 reaction equation
[ClH:1].[C:2]1([CH2:8][N:9]2[CH2:14][CH2:13][N:12](CC3C=CC=CC=3)[CH2:11][C:10]2=[O:22])[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[H][H]>C(O)C.[Pd]>[ClH:1].[C:2]1([CH2:8][N:9]2[CH2:14][CH2:13][NH:12][CH2:11][C:10]2=[O:22])[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

5

Reactant 2

HCID 233196591,4-Bis(phenylmethyl)piperazinone, hydrochlorideHCID 178418361HCID 178418361, compound2×

Product 1

HCID 127445191-Benzylpiperazin-2-one hydrochloride

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

A mixture of 1,4-bis(phenylmethyl)piperazinone hydrochloride (XIII, Example 39, 15.0 g.) and 10% palladium charcoal (5.0 g.) in ethanol (200 ml.) is hydrogenated (50 lb. initial hydrogen pressure) until uptake of hydrogen ceased. The solution is filtered, the ethanol is removed under reduced pressure and the residual solid is recrystallized from methanol-isopropanol to give the title compound, m.p. 160°-161°.

Workup

  1. filtrationThe solution is filtered
  2. customthe ethanol is removed under reduced pressure
  3. customthe residual solid is recrystallized from methanol-isopropanol

Sources & evidence

ORD record
ord-2912c64e05e84b56a66a9a09cc08b90d
Source dataset
uspto-grants-1985_08
Patent number
US04534897

Reaction notes

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