1-Methyl-3-(2-methylpropyl)-4-(phenylmethyl)piperazinone → 3-Isobutyl-1-methyl-piperazin-2-one

HRID 484974Notes

Reaction equation

HRID 484974 reaction equation
[CH3:1][N:2]1[CH2:7][CH2:6][N:5](CC2C=CC=CC=2)[CH:4]([CH2:15][CH:16]([CH3:18])[CH3:17])[C:3]1=[O:19].[H][H]>CO.[Pd]>[CH3:1][N:2]1[CH2:7][CH2:6][NH:5][CH:4]([CH2:15][CH:16]([CH3:17])[CH3:18])[C:3]1=[O:19]

Participants

5

Reactant 2

HCID 233196871-Methyl-3-(2-methylpropyl)-4-(phenylmethyl)piperazinoneHCID 178418361HCID 178418361, compound2×

Product 1

HCID 233196533-Isobutyl-1-methyl-piperazin-2-one

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

1-Methyl-3-(2-methylpropyl-4-(phenylmethyl)piperazinone (Example 47, 2.1 g.) is dissolved in methanol (200 ml.), 10% palladium charcoal (1.0 g.) is added and the product is hydrogenated (50 lb. initial hydrogen pressure until the uptake of hydrogen ceased. The solution is filtered and the methanol is removed under reduced pressure to give the title compound as an oil.

Workup

  1. filtrationThe solution is filtered
  2. customthe methanol is removed under reduced pressure

Sources & evidence

ORD record
ord-767e9111f8674f5ea0537ba433f0226d
Source dataset
uspto-grants-1985_08
Patent number
US04534897

Reaction notes

Loading…