Sodium hydride → HCID 54223591, compound

Participants

Reaction Conditions

Reaction Steps

To a suspension of NaH (2g of 50% reagent) in 100 ml of tetrahydrofuran (THF), stirred under an atmosphere of nitrogen at 0° C., (ice bath), was added dropwise 8.8 g (37 mmol) of triethyl 2-phosphonopropionate. The resulting mixture was stirred in the ice bath for additional 2.5 hrs and a solution of 5-(4-methoxy-2,3,6-trimethylphenyl)-penta-2,4-dien-1-al (8.4 g, 37 mmol) in 20 ml of THF was added. The mixture was stirred at room temperature for 4 hrs.

Provenance & Evidence