Pyridine → HCID 86740242, compound

HRID 484991Notes

Reaction equation

HRID 484991 reaction equation
[CH2:1]([O:3][C:4]([C@H:6]([O:8][C@H:9]1[N:12]([CH:13]([C:15]([O:17][CH:18]([C:25]2[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=2)[C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=2)=[O:16])O)[C:11](=[O:31])[C@@H:10]1[NH:32][C:33](=[O:40])[C:34]1[CH:39]=[CH:38][CH:37]=[CH:36][CH:35]=1)[CH3:7])=[O:5])[CH3:2].N1C=CC=CC=1.S(Cl)([Cl:49])=O>C(Cl)Cl>[CH2:1]([O:3][C:4]([C@H:6]([O:8][C@H:9]1[N:12]([CH:13]([C:15]([O:17][CH:18]([C:25]2[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=2)[C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=2)=[O:16])[Cl:49])[C:11](=[O:31])[C@@H:10]1[NH:32][C:33](=[O:40])[C:34]1[CH:39]=[CH:38][CH:37]=[CH:36][CH:35]=1)[CH3:7])=[O:5])[CH3:2]

Participants

5

Reactant 3

HCID 1049PyridineHCID 24386Thionyl ChlorideHCID 70448709HCID 70448709, compound

Product 1

HCID 86740242HCID 86740242, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

4.58 g of the product from step (2) above was dissolved in 50 ml of methylene chloride, and to the solution after ice-cooling were added 1.38 g of pyridine and 2.08 g of thionyl chloride, followed by agitation for 30 minutes to effect the chlorination.

Workup

  1. temperatureto the solution after ice-cooling

Sources & evidence

ORD record
ord-0258ff153f684794b91326ae48b4811e
Source dataset
uspto-grants-1985_08
Patent number
US04534898

Reaction notes

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