Trifluoromethanesulfonic acid → HCID 14659823, compound

Participants

Reaction Steps

10 Grams of (1R,5S)-3-phenyl-6-(1-diphenylmethoxycarbonyl-2-methylprop-1-enyl)-7-oxo-4-oxa-2,6-diazabicyclo[3,2,0]hept-2-ene as used in Example 9(1) was dissolved in 35 ml of L-(+)-lactic acid ethyl ester instead of the DL-α-lactic acid ethyl ester employed in Reference Example 1(1). To the resultant solution was added 0.5 ml of trifluoromethanesulfonic acid, and the mixture was stirred at ambient temperature for 1.5 hours. The reaction solution thus obtained was poured into 200 ml of aqueous sodium bicarbonate and allowed to stand under ice-cooling for 30 minutes.

Provenance & Evidence