HuagongsheHuagongshe Chemistry Print Report · For research reference only
Phosphorus oxychloride → Ethyl 2-[2-(4-fluorophenyl)-5-isopropyl-4-oxazolyl]acetate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Phosphorus oxychloride | HCID 24813 | — |
| Reactant | Ethyl 3-(4-fluorobenzoylamino)-3-isobutyrylpropionate | HCID 14269213 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | Ethyl 2-[2-(4-fluorophenyl)-5-isopropyl-4-oxazolyl]acetate | HCID 13488808 | 60.7% |
Reaction Steps
7.0 g of ethyl 3-(4-fluorobenzoylamino)-3-isobutyrylpropionate, 35 ml of dimethylformamide and 5.7 g of phosphorus oxychloride are treated in the same manner as described in Example 1. 4.0 g of ethyl 2-[2-(4-fluorophenyl)-5-isopropyl-4-oxazolyl]acetate are thereby obtained. Yield: 60.6%.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04535089 |
| Source dataset | uspto-grants-1985_08 |
| ORD ID | ord-74671d4c6d534ecbbe8ad06458d559fd |
| Source note | uspto-grants-1985_08 |