HuagongsheHuagongshe Chemistry Print Report · For research reference only
Phosphorus oxychloride → Ethyl 2-[2-(4-chlorophenyl)-5-isobutyl-4-oxazolyl]acetate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Phosphorus oxychloride | HCID 24813 | — |
| Reactant | Ethyl 3-(4-chlorobenzoylamino)-3-isovalerylpropionate | HCID 13488803 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | Ethyl 2-[2-(4-chlorophenyl)-5-isobutyl-4-oxazolyl]acetate | HCID 13488809 | 63.4% |
Reaction Steps
2.5 g of ethyl 3-(4-chlorobenzoylamino)-3-isovalerylpropionate, 10 ml of dimethylformamide and 2.3 g of phosphorus oxychloride are treated in the same manner as described in Example 1. 1.5 g of ethyl 2-[2-(4-chlorophenyl)-5-isobutyl-4-oxazolyl]acetate are thereby obtained. Yield: 63.3%.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04535089 |
| Source dataset | uspto-grants-1985_08 |
| ORD ID | ord-dbab9ff1965e449eaa0ccf8d6cf3a510 |
| Source note | uspto-grants-1985_08 |